Sere-Calm

$49.00

  • Promotes Relaxation Without Drowsiness*
  • Supports Nervous System Health and Function*
  • May Support Blood Pressure Already Within the Normal Range*
  • Supports Antioxidant and Detoxification Mechanisms
  • May Support Liver Health and Function*

Description

Discussion

Green tea, prepared from the Camellia sinensis plant, has been consumed since ancient times for its calming influence. Modern research has looked into this “ancient wisdom” and revealed that L-theanine, an amino acid found almost exclusively in green tea, has specific and positive effects on the brain and nervous system, especially the promotion of relaxation without drowsiness.*

Neurological and Brain Support Human studies suggest that within 40 minutes of oral administration, L-theanine positively affected alpha waves in the brain, a phenomenon indicating relaxation. An eight-week, randomized, double-blind, placebo-controlled study, based on the premise that L-theanine “possesses neuroprotective, mood-enhancing, and relaxation properties,” suggested that 400 mg of L-theanine
per day was found to be safe and effective. A double-blind counterbalanced study suggested that oral L-theanine positively influenced heart rate and salivary IgA levels, attenuated sympathetic nervous system activation, and positively supported individuals’ normal response to stress. In examining L-theanine’s effect on cognition, a randomized, double-blind, placebo-controlled study of 91 subjects suggested that individuals taking a combination of L-theanine and green tea extract experienced significant increases in theta waves in several areas of the brain, indicative of increased cognitive alertness.*

In cell studies, L-theanine appears to support neuronal health despite the presence of environmental toxins that ordinarily would increase the vulnerability of nigral dopaminergic neurons and negatively affect their function. L-theanine also appears to support neurological health by exerting a positive and significant impact on neurotrophic factors in the brain and assisting cell-signaling activity.*

Research into animal neurochemistry suggests that L-theanine positively supports overall nervous system health and activity due to its
positive effects on serotonin, dopamine, and GABA levels, as well as its modulation of excitatory and inhibitory neurotransmission.

L-theanine crosses the blood-brain barrier intact and may continue to balance neurochemistry by blocking glutamate transport, significantly reducing levels of extracellular glutamate and supporting the release of dopamine and glycine from neurons.*

Hepatic, Detoxification, and Cardiovascular Support Research studying ethanol metabolism and hepatic toxicity in animals suggests that administration of L-theanine increases liver alcohol dehydrogenase and aldehyde dehydrogenase activity, reducing blood ethanol concentration within one hour compared to controls. It is also suggested that L-theanine’s effect on cytochrome P450 2E1 activity,
glutathione recovery, and antioxidant mechanisms supports healthy liver tissue and function. L-theanine was observed to significantly inhibit hydrogen peroxide-induced cell death, and it may play an important role in the maintenance of liver health. L-theanine, along with green tea polyphenols, was found to provide antioxidant activity that supports healthy LDL and oxidation levels and may subsequently
support cardiovascular health. Animal and human studies suggest that L-theanine supports healthy blood pressure in the normal range, in part because it moderates the negative side effects of caffeine.*

L-theanine and Suntheanine®

Although theanine exists in both L- and D- forms, L-theanine is the preferred form due to its greater
intestinal absorption and renal retention. An analysis of six commercial products revealed that five of them contained the poorly absorbed D-theanine along with L-theanine. Only Suntheanine, the brand in CinDen Nutritionals’ Sere-Calm, appeared to contain only the preferred L-theanine enantiomer. Suntheanine is protected by several patents that cover applications, such as reducing anxiety and promoting relaxation. The FDA has consequently approved the following structure/function claims regarding L-theanine: it reduces stress, it eases nervousness due to common everyday overwork and fatigue, and it reduces nervous irritability. CinDen Nutritionals’s Sere-Calm provides 400 mg of Suntheanine L-theanine per two-capsule dose.*

References

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  2. Ritsner MS, Miodownik C, Ratner Y, et al. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind, placebo-controlled, 2-center study. J Clin Psychiatry. 2011 Jan;72(1):34-42. [PMID: 21208586]
  3. Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45. [PMID: 16930802]
  4. Park SK, Jung IC, Lee WK, et al. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food. 2011 Apr;14(4):334-43. [PMID: 21303262]
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  6. Yokogoshi H, Kobayashi M, Mochizuki M, et al. Effect of theanine, r-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res. 1998 May;23(5):667-73. [PMID: 9566605]
  7. Nathan PJ, Lu K, Gray M, et al. The neuropharmacology of L-theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30. Review. [PMID: 17182482]
  8. Yamada T, Terashima T, Okubo T, et al. Effects of theanine, r-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission. Nutr Neurosci. 2005 Aug;8(4):219-26. [PMID: 16493792]
  9. Kakuda T, Hinoi E, Abe A, et al. Theanine, an ingredient of green tea, inhibits [3H]glutamine transport in neurons and astroglia in rat brain. J Neurosci Res. 2008 Jun;86(8):1846-56. [PMID: 18293419]
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  12. Sugiyama T, Sadzuka Y. Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level. Cancer Lett. 2004 Aug 30;212(2):177-84. [PMID: 15279898]
  13. Li G, Kang J, Yao X, et al. The component of green tea, L-theanine protects human hepatic L02 cells from hydrogen peroxide-induced apoptosis. European food research & technology (Internet). 2011;233(3):427-35. http://cat.inist.fr/?aModele=afficheN&cpsidt=24465632. Accessed March 28, 2012.
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  18. NutriScience Innovations. Suntheanine®. http://www.nutriscienceusa.com/npSuntheanine.htm. Accessed March 29, 2012.
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  21. Suntheanine®. What is Suntheanine? http://www.suntheanine.com/WhatIsSuntheanine.cfm. Accessed March 29, 2012.
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123 A Scurfield Blvd
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